Could nucleolin and nucleophosmin levels be prognostic indicators in non-small cell lung cancer?

Aim: Lung cancer is the leading cause of mortality from across world. In this study, use serum nucleolin (NCL) and nucleophosmin (NPM1) levels as a marker in diagnosis, prognosis treatment response evaluation lung was investigated. Materials Method: NCL NPM1 samples taken before chemotherapy after 3-4 courses control group patients diagnosed with were studied using ELISA method. Results: Serum higher than controls (p = 0.085 for NCL, p 0.000 NPM1). by histopathologic type significantly adenocarcinoma squamous cell carcinoma < 0.05 each). view responses to chemotherapeutic agents, there statistically insignificant difference between values > Conclusion: High found correlate poor prognosis, low survival rate. It can be concluded that used diagnostic prognostic markers disease.